{"schema_version":"secwatch.filing_event.v1","accession":"0001193125-26-428306","form_type":"8-K","ticker":"KRRO","cik":"0001703647","company_name":"Korro Bio, Inc.","filed_at":"2026-10-22T11:04:13+00:00","discovered_at":"2026-10-22T11:05:00.295495+00:00","generated_at":"2026-10-22T11:05:05.013021+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Korro's KRRO-111 shows 96% SERPINA1 editing, 95% liver Z-AAT cut; 1H 2027 filing planned","bullets":["In NSG-PiZ mice, repeat-dose KRRO-111 reached 96% SERPINA1 mRNA editing, with M-AAT at 93% of circulating AAT and total AAT of 172 μM (~6-fold vs vehicle) at Day 57.","In immunocompetent C57BL/6-PiZ mice, KRRO-111 reduced whole-liver Z-AAT by 95% versus vehicle at Day 57, measured by LC-MS/MS.","Single-dose C57BL/6-PiZ: up to 91% editing and M-AAT up to 88% of total AAT, detectable through Day 42; EC50 ~1 nM, up to 98% editing in mouse and human hepatocytes.","KRRO-111 is a subcutaneous GalNAc-conjugated oligonucleotide using ADAR to correct the pathogenic SERPINA1 transcript; Korro expects a regulatory submission in 1H 2027.","CSO Loïc Vincent said the dual profile restores functional M-AAT while cutting toxic Z-AAT; CEO Ram Aiyar said Korro plans to advance KRRO-111 into the clinic in 1H 2027."],"urls":{"canonical":"https://secwatch.observer/filing/0001193125-26-428306","json":"https://secwatch.observer/filing/0001193125-26-428306.json","markdown":"https://secwatch.observer/filing/0001193125-26-428306.md","text":"https://secwatch.observer/filing/0001193125-26-428306.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1703647/000119312526428306/0001193125-26-428306-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1703647/000119312526428306/krro-20261022.htm"},"model":{"generated_by":"deepseek-v4.1-flash:cloud@v2","generated_at":"2026-10-22T11:05:05.013021+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}