Arcturus ARCT-810 Phase 2 interim: glutamine normalized, ureagenesis improved (p=0.026)

Arcturus Therapeutics Holdings Inc.

Combined Phase 2 data show glutamine significantly reduced (p=0.0055); levels normalized after 3 doses in US study.
15N-ureagenesis function (RUF) increased from 29.0% baseline to 43.7% at day 28 post-fifth dose (p=0.026).
Ammonia remained stable and within normal range in both studies; one hyperammonemia event on placebo.
ARCT-810 safe and well tolerated across Phase 1/2 with no serious infusion reactions on optimized 3-hour regimen.

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