---
schema_version: "secwatch.filing_event.v1"
accession: "0001200375-23-000027"
form_type: "8-K"
ticker: "CDXS"
cik: "0001200375"
company_name: "CODEXIS, INC."
filed_at: "2023-08-03T23:59:59+00:00"
generated_at: "2026-06-12T07:18:47.392512+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.8
calibrated_materiality_score: 0.8
confidence: "high"
source: SEC EDGAR
---

# Codexis Q2 loss widens to $11.5M; pivots to ECO Synthesis RNAi platform, cuts headcount 25%

## Summary
- Net loss of $11.5M ($0.17/share) vs $2.6M loss in Q2 2022; total rev $21.3M (ex-PAXLOVID up 46% YoY).
- Prioritizing ECO Synthesis RNAi therapeutics platform; aims for gram-scale synthesis by end-2023.
- Discontinued Biotherapeutics programs; reduced headcount ~25%; consolidated to HQ.
- Cash $92.1M as of June 30; projected runway extended to mid-2026.
- FY 2023 guidance reiterated: product rev $30-35M (ex-PAXLOVID), R&D rev $21-24M, gross margin 55-65%.

## SEC filing metadata
- accession: 0001200375-23-000027
- form_type: 8-K
- ticker: CDXS
- cik: 0001200375
- company_name: CODEXIS, INC.
- filed_at: 2023-08-03T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.8
- calibrated_materiality_score: 0.8
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1200375/000120037523000027/0001200375-23-000027-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1200375/000120037523000027/cdxs-20230803.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001200375-23-000027
- JSON: https://secwatch.observer/filing/0001200375-23-000027.json
- Plain text: https://secwatch.observer/filing/0001200375-23-000027.txt

## Key facts
- Earnings Releases
  CODEXIS, INC. updated its second quarter ended June 30, 2023 guidance (reaffirmed).
  - Period: second quarter ended June 30, 2023
  - Guidance: reaffirmed
  - Result: reported results
  source text: Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company, today announced financial results for the second quarter ended June 30, 2023, and provided a business update.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1200375/000120037523000027/0001200375-23-000027-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.