---
schema_version: "secwatch.filing_event.v1"
accession: "0001213900-21-061000"
form_type: "8-K"
ticker: "RFL"
cik: "0001713863"
company_name: "Rafael Holdings, Inc."
filed_at: "2021-11-22T23:59:59+00:00"
generated_at: "2026-06-28T06:10:01.061775+00:00"
event_type: "leadership"
sentiment: "negative"
materiality_score: 0.85
calibrated_materiality_score: 0.85
confidence: "high"
source: SEC EDGAR
---

# Rafael Holdings CEO Ameet Mallik to step down; Howard Jonas named CEO after disappointing trial results

## Summary
- CEO Ameet Mallik resigns effective Jan 31, 2022; remains on board and chairs new Transition Committee.
- Chairman Howard Jonas named CEO effective Feb 1, 2022; he previously served as CEO from March 2018 to April 2021.
- CFO Patrick Fabbio also named President; all options to vest Sept 30, 2026; severance terms amended.
- Chief Commercial Officer William Conkling, Chief Legal Officer, Chief Corporate Affairs Officer, and Chief Compliance Officer depart by end of January 2022.
- Leadership realignment follows disappointing Phase 3 results for CPI-613 (devimistat) in pancreatic cancer and AML.

## SEC filing metadata
- accession: 0001213900-21-061000
- form_type: 8-K
- ticker: RFL
- cik: 0001713863
- company_name: Rafael Holdings, Inc.
- filed_at: 2021-11-22T23:59:59+00:00
- event_type: leadership
- sentiment: negative
- materiality_score: 0.85
- calibrated_materiality_score: 0.85
- confidence: high
- sec_items: 5.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1713863/000121390021061000/0001213900-21-061000-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1713863/000121390021061000/ea151164-8k_rafaelhold.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001213900-21-061000
- JSON: https://secwatch.observer/filing/0001213900-21-061000.json
- Plain text: https://secwatch.observer/filing/0001213900-21-061000.txt

## Key facts
- Executive change
  William Conkling departed as Chief Commercial and Business Officer at Rafael Holdings, Inc..
  - Action: depart
  - Role: Chief Commercial and Business Officer
  source text: On November 21, 2021, the Board of Directors decided that William Conkling will depart as the Company’s Chief Commercial and Business Officer, effective January 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1713863/000121390021061000/0001213900-21-061000-index.htm
- Executive change
  Howard Jonas was elected as Chief Executive Officer at Rafael Holdings, Inc..
  - Action: elected
  - Role: Chief Executive Officer
  source text: On November 21, 2021, the Company’s Board of Directors (i) elected Howard Jonas, the Company’s Chairman of the Board, as the Company’s Chief Executive Officer, effective February 1, 2022
  evidence_url: https://www.sec.gov/Archives/edgar/data/1713863/000121390021061000/0001213900-21-061000-index.htm
- Executive change
  Patrick Fabbio was elected as President at Rafael Holdings, Inc..
  - Action: elected
  - Role: President
  source text: elected Patrick Fabbio, the Company’s Chief Financial Officer, as President in addition to his role as the Chief Financial Officer.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1713863/000121390021061000/0001213900-21-061000-index.htm
- Executive change
  Ameet Mallik resigned as Chief Executive Officer at Rafael Holdings, Inc..
  - Action: resigned
  - Role: Chief Executive Officer
  source text: On November 21, 2021, Ameet Mallik resigned as Chief Executive Officer of Rafael Holdings, Inc. (the “Company”), effective January 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1713863/000121390021061000/0001213900-21-061000-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.