Cadrenal Therapeutics acquires eXIthera's Factor XIa inhibitors for up to $15M in milestones

Cadrenal Therapeutics, Inc.

Acquires frunexian (Phase 2-ready IV FXIa) and EP-7327 (IND-ready oral FXIa) from eXIthera.
Total contingent milestone payments up to $15M plus royalties on global sales; $50K cash paid at closing.
Deal closed September 12, 2025; Cadrenal now sole developer of both a VKA (tecarfarin) and FXIa inhibitors.
Plans Phase 2 study for frunexian in complex cardiac surgery with first patient expected in 1Q27.
eXIthera to receive 2% royalty on net sales outside China and 50% of sublicense royalties from Haisco.

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