{"schema_version":"secwatch.filing_event.v1","accession":"0001213900-26-011844","form_type":"8-K","ticker":"CERO","cik":"0001870404","company_name":"CERO THERAPEUTICS HOLDINGS, INC.","filed_at":"2026-02-04T23:59:59+00:00","discovered_at":"2026-05-14T18:02:36.623414+00:00","generated_at":"2026-05-16T05:02:32.588889+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"CER-1236 first-in-human data show no CRS/ICANS; platelet transfusion independence in index AML patient","bullets":["No cytokine release syndrome (CRS) or ICANS observed despite CD28 costimulatory domain and measurable cell expansion.","Index patient with inv(3) AML achieved platelet transfusion independence for 72 days after multiple CER-1236 doses.","CER-1236 successfully manufactured for all four enrolled patients; study expanded to include MDS and myelofibrosis.","TIM-4 ligand target expressed on AML but not healthy bone marrow; no off-tumor cytotoxicity in preclinical safety assays."],"urls":{"canonical":"https://secwatch.observer/filing/0001213900-26-011844","json":"https://secwatch.observer/filing/0001213900-26-011844.json","markdown":"https://secwatch.observer/filing/0001213900-26-011844.md","text":"https://secwatch.observer/filing/0001213900-26-011844.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1870404/000121390026011844/0001213900-26-011844-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1870404/000121390026011844/ea0275412-8k_cero.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-16T05:02:32.588889+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}