{"schema_version":"secwatch.filing_event.v1","accession":"0001213900-26-026646","form_type":"8-K","ticker":"CVKD","cik":"0001937993","company_name":"Cadrenal Therapeutics, Inc.","filed_at":"2026-03-12T23:59:59+00:00","discovered_at":"2026-05-14T18:02:36.825730+00:00","generated_at":"2026-05-15T13:55:44.772525+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.55,"calibrated_materiality_score":0.55,"confidence":"high","headline":"Cadrenal 12-LOX inhibitor CAD-1005 shows preclinical benefits in obesity and Type 2 diabetes","bullets":["Preclinical data: CAD-1005 improved glycemic control, reduced pancreatic β-cell loss, and lowered inflammatory cells in adipose/pancreatic tissues.","CAD-1005 also evaluated for HIT; Phase 2 trial reduced thrombotic events. Company acquired 12-LOX portfolio in Dec 2025.","Company believes CAD-1005 is the only clinical-stage 12-LOX inhibitor and may complement GLP-1 obesity drugs.","CEO highlights broader potential of 12-LOX inhibition beyond HIT; interested in partnerships."],"urls":{"canonical":"https://secwatch.observer/filing/0001213900-26-026646","json":"https://secwatch.observer/filing/0001213900-26-026646.json","markdown":"https://secwatch.observer/filing/0001213900-26-026646.md","text":"https://secwatch.observer/filing/0001213900-26-026646.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1937993/000121390026026646/0001213900-26-026646-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1937993/000121390026026646/ea0281315-8k_cadrenal.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-15T13:55:44.772525+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}