Profusa, Inc. (PFSA): debt financing — Profusa Issues $1.11M Convertible Note and Warrant to Ascent Partners Fund LLC

the Company issued to Ascent (i) a Senior Secured Convertible Promissory Note in the aggregate principal amount of $1,111,111.11 (the “ Note ”) and (ii) a Warrant to Purchase Shares of common stock of Profusa, Inc. entitling Ascent to purchase up to 3,333,333 shares of the Company’s common stock, par value $0.0001 per share (the “ Warrant ”), for an aggregate purchase price of $1,000,000.

On April 20, 2026, Profusa, Inc., a Delaware corporation (the “ Company ”), completed an additional closing under that certain Securities Purchase Agreement, dated as of February 11, 2025 (as amended, the “ Purchase Agreement ”), by and among the Company, Ascent Partners Fund LLC, a Delaware limited liability company (“ Ascent ”), as initial purchaser, and Ascent, as collateral agent for the purchasers party thereto. In connection with the additional closing, the Company issued to Ascent (i) a Senior Secured Convertible Promissory Note in the aggregate principal amount of $1,111,111.11 (the “ Note ”)

Ascent Partners Fund LLC also entered into a Lock-Up Agreement (the “ Lock-Up Agreement ”) with the Company, dated as of April 20, 2026.

f the Warrant, the Company also entered into a side letter agreement (the “ Side Letter ”) with Ascent. Pursuant to the Side Letter, (i) Ascent waived certain defaults under the Purchase Agreement related to the timing of the delivery of the warrant

(ii) a Warrant to Purchase Shares of common stock of Profusa, Inc. entitling Ascent to purchase up to 3,333,333 shares of the Company’s common stock, par value $0.0001 per share (the “ Warrant ”), for an aggregate purchase price of $1,000,000.