{"schema_version":"secwatch.filing_event.v1","accession":"0001213900-26-096235","form_type":"8-K","ticker":"PLYX","cik":"0002075320","company_name":"Polaryx Therapeutics, Inc.","filed_at":"2026-09-01T20:30:15+00:00","discovered_at":"2026-09-01T20:31:03.442261+00:00","generated_at":"2026-09-01T20:31:32.371386+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"leadership","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Polaryx appoints Dr. Will Charlton as Chief Medical Officer; SOTERIA Phase 2 on track for Q4 2026","bullets":["Dr. Charlton appointed CMO effective Sept 1, 2026; brings 15+ years rare disease/pediatric drug development experience.","Previously SVP Clinical Development at Tyra Biosciences; led Phase 2 rare disease trial; also CMO at Spruce Biosciences.","SOTERIA Phase 2 trial of PLX-200 in CLN2, CLN3, Krabbe, Sandhoff diseases; FDA safe-to-proceed Oct 2025; initiation planned Q4 2026.","Dr. Charlton's background includes roles at 89bio, Ascendis Pharma, Allergan; board-certified pediatric endocrinologist."],"urls":{"canonical":"https://secwatch.observer/filing/0001213900-26-096235","json":"https://secwatch.observer/filing/0001213900-26-096235.json","markdown":"https://secwatch.observer/filing/0001213900-26-096235.md","text":"https://secwatch.observer/filing/0001213900-26-096235.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/2075320/000121390026096235/0001213900-26-096235-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/2075320/000121390026096235/ea0303928-8k_polaryx.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-01T20:31:32.371386+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}