{"schema_version":"secwatch.filing_event.v1","accession":"0001326190-22-000016","form_type":"8-K","ticker":"ALT","cik":"0001326190","company_name":"Altimmune, Inc.","filed_at":"2022-12-20T23:59:59+00:00","discovered_at":"2026-05-14T18:03:50.161574+00:00","generated_at":"2026-06-21T01:31:58.640306+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Altimmune reports positive 24-week pemvidutide NAFLD trial: >75% liver fat reduction, 7.2% weight loss at 1.8 mg","bullets":["At 1.8 mg dose, mean relative liver fat reduction 75.2%; 53.8% achieved normalization (≤5% LFC).","Mean weight loss of 7.2% (placebo-adjusted 6.0%) in non-diabetic subjects at 1.8 mg dose.","Significant ALT declines: ≥17 IU/L reduction in subjects with baseline ALT ≥30 IU/L across all doses.","cT1 response (≥80 ms reduction) achieved in 75% (1.8 mg) and 100% (2.4 mg) of evaluated subjects.","Pemvidutide well tolerated; 3 serious/severe AEs unrelated to drug; no significant ALT elevations."],"urls":{"canonical":"https://secwatch.observer/filing/0001326190-22-000016","json":"https://secwatch.observer/filing/0001326190-22-000016.json","markdown":"https://secwatch.observer/filing/0001326190-22-000016.md","text":"https://secwatch.observer/filing/0001326190-22-000016.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1326190/000132619022000016/0001326190-22-000016-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1326190/000132619022000016/alt-20221220x8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-21T01:31:58.640306+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}