---
schema_version: "secwatch.filing_event.v1"
accession: "0001326732-24-000002"
form_type: "8-K"
ticker: "XNCR"
cik: "0001326732"
company_name: "Xencor Inc"
filed_at: "2024-02-27T23:59:59+00:00"
generated_at: "2026-06-05T10:57:22.865466+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Xencor Q4 2023 net loss $19.1M ($0.31 EPS); cash $697.4M; workforce cut ~10%

## Summary
- Q4 2023 revenue $44.7M vs $21.6M YoY; full-year net loss $126.1M ($2.08) vs $55.2M ($0.93) in 2022.
- Cash and marketable securities $697.4M at Dec 31, 2023; guidance for end-2024 $475M-$525M, runway into 2027.
- Vudalimab in high-risk mCRPC showed 33% ORR (4/12) and PSA90 in 25%; plans to advance or decide by H1 2025.
- J&J milestones: $27.5M in Q4 2023; two new CD28 candidates selected; workforce cut ~10% in Jan 2024.
- Pausing cytokine programs XmAb564 (IL2-Fc) and XmAb662 (IL12-Fc) after data review; dosing first patient for XmAb541 in H1 2024.

## SEC filing metadata
- accession: 0001326732-24-000002
- form_type: 8-K
- ticker: XNCR
- cik: 0001326732
- company_name: Xencor Inc
- filed_at: 2024-02-27T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1326732/000132673224000002/0001326732-24-000002-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1326732/000132673224000002/xncr-20240227.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001326732-24-000002
- JSON: https://secwatch.observer/filing/0001326732-24-000002.json
- Plain text: https://secwatch.observer/filing/0001326732-24-000002.txt

## Key facts
- Earnings Releases
  Xencor Inc reported financial results for the fourth quarter and fiscal year ended December 31, 2023.
  - Period: the fourth quarter and fiscal year ended December 31, 2023
  - Result: reported results
  source text: On February 27, 2024, Xencor, Inc. announced its financial results for the fourth quarter and fiscal year ended December 31, 2023 in the press release attached hereto as Exhibit 99.1 and incorporated herein by reference.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1326732/000132673224000002/0001326732-24-000002-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.