---
schema_version: "secwatch.filing_event.v1"
accession: "0001326732-26-000042"
form_type: "8-K"
ticker: "XNCR"
cik: "0001326732"
company_name: "Xencor Inc"
filed_at: "2026-05-06T23:59:59+00:00"
generated_at: "2026-05-14T22:33:50.732783+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Xencor reports Q1 net loss $128.9M ($1.71/shr); revenue down to $4.5M from $32.7M

## Summary
- Q1 2026 revenue $4.5M (vs $32.7M Q1 2025), including a $6.6M one-time reduction from Alexion royalty dispute.
- Net loss $128.9M ($1.71 diluted), vs $48.4M ($0.66) in prior year; other expense $50.8M on unrealized equity losses.
- Cash $541.8M at March end; guidance for year-end cash $380-400M, runway into mid-2028.
- XmAb819 ccRCC expansion data to be presented 2H26; XmAb541 dose data also 2H26; XmAb412 FIH starts 3Q26.
- XENITH-UC Phase 2b (XmAb942) blinded interim analysis around year-end 2026; primary endpoint 2H27.

## SEC filing metadata
- accession: 0001326732-26-000042
- form_type: 8-K
- ticker: XNCR
- cik: 0001326732
- company_name: Xencor Inc
- filed_at: 2026-05-06T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1326732/000132673226000042/0001326732-26-000042-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1326732/000132673226000042/xncr-20260506.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001326732-26-000042
- JSON: https://secwatch.observer/filing/0001326732-26-000042.json
- Plain text: https://secwatch.observer/filing/0001326732-26-000042.txt

## Source-grounded claims
- claim_id: 812082bd67e0590aceb1957622735fdc0301e60b
  claim: Xencor Inc reported the first quarter ended March 31, 2026 results: revenue $4.5 million. Guidance reaffirmed.
  evidence_excerpt: debt securities totaled $541.8 million as of March 31, 2026, compared to $610.8 million as of December 31, 2025. Revenue for the first quarter ended March 31, 2026 was $4.5 million, compared to $32.7 million for the same period in 2025. Revenue earned in the first quarter of 2026 was primarily non-cash royalty revenue from Incyte and Alexion, compared to
  evidence_url: https://www.sec.gov/Archives/edgar/data/1326732/000132673226000042/0001326732-26-000042-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.