{"schema_version":"secwatch.filing_event.v1","accession":"0001339970-26-000065","form_type":"8-K","ticker":"ATYR","cik":"0001339970","company_name":"aTYR PHARMA INC","filed_at":"2026-09-24T11:47:35+00:00","discovered_at":"2026-09-24T11:55:10.414000+00:00","generated_at":"2026-09-24T11:55:17.888266+00:00","sec_items":["8.01"],"event_type":"regulatory","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"aTyr Pharma reaches FDA alignment on Phase 3 protocol for efzofitimod in pulmonary sarcoidosis","bullets":["Study to start Q4 2026; global, randomized, double-blind, placebo-controlled, 54-week trial.","Two parallel cohorts: 5.0 mg/kg efzofitimod vs placebo IV every 3 weeks for 17 doses; up to 372 patients.","Primary endpoint: change from baseline FVC at week 48; key secondary: KSQ-Lung score change at week 48.","Design supported by EFZO-FIT subgroup data showing clinically meaningful FVC and patient-reported improvements.","Company expects to need additional capital via equity/debt, grants, collaborations, or licensing for study."],"urls":{"canonical":"https://secwatch.observer/filing/0001339970-26-000065","json":"https://secwatch.observer/filing/0001339970-26-000065.json","markdown":"https://secwatch.observer/filing/0001339970-26-000065.md","text":"https://secwatch.observer/filing/0001339970-26-000065.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1339970/000133997026000065/0001339970-26-000065-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1339970/000133997026000065/atyr-20260924.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-24T11:55:17.888266+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}