{"schema_version":"secwatch.filing_event.v1","accession":"0001356576-24-000058","form_type":"8-K","ticker":"SUPN","cik":"0001356576","company_name":"SUPERNUS PHARMACEUTICALS, INC.","filed_at":"2024-10-17T23:59:59+00:00","discovered_at":"2026-05-14T18:03:08.247091+00:00","generated_at":"2026-05-30T13:12:16.728927+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Supernus SPN-820 Phase 2a data: rapid depressive symptom reduction with favorable tolerability","bullets":["HAM-D6 score improved -6.1 at 2 hours, -9.6 at Day 10; MADRS improved -16.6 at 4 hours, -22.9 at Day 10.","Suicidal ideation decreased 80% (from 12.5% to 2.6%) over 10 days.","SPN-820 well-tolerated; discontinuation rate 2.5% due to AEs; common AEs: headache, nausea, somnolence, dizziness.","Study enrolled 40 subjects; 38 completed 10-day treatment; open-label, adjunctive to baseline antidepressant.","Phase 2b double-blind placebo-controlled study topline results expected first-half 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001356576-24-000058","json":"https://secwatch.observer/filing/0001356576-24-000058.json","markdown":"https://secwatch.observer/filing/0001356576-24-000058.md","text":"https://secwatch.observer/filing/0001356576-24-000058.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1356576/000135657624000058/0001356576-24-000058-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1356576/000135657624000058/supn-20241017.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-30T13:12:16.728927+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}