Milestone Scientific dismisses Friedman LLP, appoints Marcum as auditor after merger

MILESTONE SCIENTIFIC INC.

Audit committee approved dismissal of Friedman LLP and engagement of Marcum LLP effective October 13, 2022.
Friedman merged with Marcum effective September 1, 2022; services now provided by Marcum.
No disagreements or reportable events with Friedman in fiscal years 2020 and 2021 or subsequent interim period.
Friedman's audit reports for 2020 and 2021 contained no adverse opinion or qualification.
Friedman furnished a letter to the SEC agreeing with the disclosures, attached as Exhibit 16.1.

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