---
schema_version: "secwatch.filing_event.v1"
accession: "0001437749-23-008429"
form_type: "8-K"
ticker: "DYAI"
cik: "0001213809"
company_name: "DYADIC INTERNATIONAL INC"
filed_at: "2023-03-29T23:59:59+00:00"
generated_at: "2026-06-17T10:00:32.913294+00:00"
event_type: "earnings"
sentiment: "positive"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Dyadic reports 2022 revenue up 21.9% to $2.93M; net loss narrows to $9.7M; COVID-19 vaccine trial dosing complete

## Summary
- Revenue $2.93M (+21.9% YoY); net loss $9.7M ($0.34/share) vs $13.1M ($0.47) in 2021.
- Cash $12.7M at year-end; received $1.27M from Alphazyme sale in Jan 2023; expects to fund ops into 2024.
- Phase 1 trial of DYAI-100 COVID-19 booster: dosing complete in low/high dose groups, no serious adverse events; full report H2 2023.
- Collaborations with Janssen, Phibro/Abic, global food ingredient company; Dapibus platform progress.
- Five peer-reviewed publications on C1-cell platform; new corporate website.

## SEC filing metadata
- accession: 0001437749-23-008429
- form_type: 8-K
- ticker: DYAI
- cik: 0001213809
- company_name: DYADIC INTERNATIONAL INC
- filed_at: 2023-03-29T23:59:59+00:00
- event_type: earnings
- sentiment: positive
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1213809/000143774923008429/0001437749-23-008429-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1213809/000143774923008429/dyai20221121_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001437749-23-008429
- JSON: https://secwatch.observer/filing/0001437749-23-008429.json
- Plain text: https://secwatch.observer/filing/0001437749-23-008429.txt

## Key facts
- Earnings Releases
  DYADIC INTERNATIONAL INC reported financial results for year ended December 31, 2022.
  - Period: year ended December 31, 2022
  - Result: reported results
  source text: On March 29, 2023, Dyadic International, Inc. (“Dyadic”, or the “Company”) issued a press release announcing its financial results for the quarter and year ended December 31, 2022 and recent Company progress. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference except for paragraphs two, three, four and five of the press release.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1213809/000143774923008429/0001437749-23-008429-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.