{"schema_version":"secwatch.filing_event.v1","accession":"0001437749-24-026563","form_type":"8-K","ticker":"MNPR","cik":"0001645469","company_name":"Monopar Therapeutics","filed_at":"2024-08-14T23:59:59+00:00","discovered_at":"2026-05-14T18:03:13.940021+00:00","generated_at":"2026-05-31T09:21:02.873016+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Monopar doses first patient in Phase 1 MNPR-101-Zr trial; favorable safety and biodistribution data","bullets":["First patient dosed in open-label Phase 1 imaging trial of MNPR-101-Zr; well-tolerated with no serious adverse reactions.","Red bone marrow radiation dose ~14 mGy, roughly 150 times below the accepted limit of 2-3 Gy.","No unanticipated or excessive uptake in critical organs; biodistribution aligns with preclinical data.","Initial patient has metastatic cancer not known for high uPAR expression; study to include high-uPAR cancers.","COO Andrew Cittadine: data increases confidence to advance Phase 1 and prepare therapeutic study."],"urls":{"canonical":"https://secwatch.observer/filing/0001437749-24-026563","json":"https://secwatch.observer/filing/0001437749-24-026563.json","markdown":"https://secwatch.observer/filing/0001437749-24-026563.md","text":"https://secwatch.observer/filing/0001437749-24-026563.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1645469/000143774924026563/0001437749-24-026563-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1645469/000143774924026563/mnpr20240812_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T09:21:02.873016+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}