{"schema_version":"secwatch.filing_event.v1","accession":"0001437749-24-030219","form_type":"8-K","ticker":"WINT","cik":"0000946486","company_name":"WINDTREE THERAPEUTICS INC /DE/","filed_at":"2024-09-30T23:59:59+00:00","discovered_at":"2026-05-14T18:03:16.465222+00:00","generated_at":"2026-05-31T01:03:00.650145+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Windtree announces positive Phase 2b topline results for istaroxime in early cardiogenic shock","bullets":["Primary endpoint met: istaroxime significantly improved systolic blood pressure (SBP AUC) vs placebo (p=0.0070) in combined Part A/B analysis.","Istaroxime improved cardiac output by ~15%, reduced heart rate, and lowered pulmonary capillary wedge pressure (PCWP) vs placebo at multiple timepoints.","Renal function (eGFR) improved with istaroxime at 48 hours (p=0.0291); NYHA heart failure classification improved through 72 hours.","Serious adverse events were similar: 10.5% istaroxime vs 27.3% placebo; no increase in clinically significant arrythmias observed."],"urls":{"canonical":"https://secwatch.observer/filing/0001437749-24-030219","json":"https://secwatch.observer/filing/0001437749-24-030219.json","markdown":"https://secwatch.observer/filing/0001437749-24-030219.md","text":"https://secwatch.observer/filing/0001437749-24-030219.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/946486/000143774924030219/0001437749-24-030219-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/946486/000143774924030219/wint20240929_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T01:03:00.650145+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}