{"schema_version":"secwatch.filing_event.v1","accession":"0001437749-25-023646","form_type":"8-K","ticker":"CRVO","cik":"0001053691","company_name":"CervoMed Inc.","filed_at":"2025-07-28T23:59:59+00:00","discovered_at":"2026-05-14T18:02:43.214707+00:00","generated_at":"2026-05-18T00:07:00.049492+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"CervoMed reports neflamapimod 54% risk reduction on CDR-SB at Week 32 in DLB trial","bullets":["At Week 32, neflamapimod showed 54% risk reduction in >=1.5-point CDR-SB worsening vs control (p=0.0037); 64% in ptau181<2.2 patients (p=0.0001).","Significant reduction in plasma GFAP biomarker: mean change -18.4 pg/mL (p<0.0001) for New Capsules over 32 weeks.","Plans to initiate Phase 3 trial and meet with FDA in Q4 2025 to align on trial design.","New Capsules achieved target plasma exposures; Old Capsules did not; similar safety profiles.","Trial funded by $21.3M NIH/NIA grant; 43 sites across US, UK, Netherlands."],"urls":{"canonical":"https://secwatch.observer/filing/0001437749-25-023646","json":"https://secwatch.observer/filing/0001437749-25-023646.json","markdown":"https://secwatch.observer/filing/0001437749-25-023646.md","text":"https://secwatch.observer/filing/0001437749-25-023646.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1053691/000143774925023646/0001437749-25-023646-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1053691/000143774925023646/crvo20250728_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-18T00:07:00.049492+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}