---
schema_version: "secwatch.filing_event.v1"
accession: "0001437749-25-027725"
form_type: "8-K"
ticker: "PLSE"
cik: "0001625101"
company_name: "PULSE BIOSCIENCES, INC."
filed_at: "2025-08-26T23:59:59+00:00"
generated_at: "2026-05-17T09:57:26.992675+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Pulse Biosciences publishes FIH data for nsPFA thyroid nodule treatment in Thyroid journal

## Summary
- Single-arm feasibility study by Prof. Spiezia at Ospedale del Mare, Naples, Italy; three cohorts.
- Fully treated nodules (Cohort 3) showed up to 93% size reduction at 1 year (avg 86%), symptom relief as early as 2 weeks.
- No intranodular fibrosis or scarring on follow-up ultrasounds.
- nsPFA achieved 71% volume reduction in 1 month vs RFA's typical 6-month timeline for comparable shrinkage.
- Publication in peer-reviewed journal Thyroid validates safety and effectiveness for benign nodules.

## SEC filing metadata
- accession: 0001437749-25-027725
- form_type: 8-K
- ticker: PLSE
- cik: 0001625101
- company_name: PULSE BIOSCIENCES, INC.
- filed_at: 2025-08-26T23:59:59+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1625101/000143774925027725/0001437749-25-027725-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1625101/000143774925027725/plse20250825_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001437749-25-027725
- JSON: https://secwatch.observer/filing/0001437749-25-027725.json
- Plain text: https://secwatch.observer/filing/0001437749-25-027725.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.