{"schema_version":"secwatch.filing_event.v1","accession":"0001437749-25-029005","form_type":"8-K","ticker":"MNPR","cik":"0001645469","company_name":"Monopar Therapeutics","filed_at":"2025-09-15T23:59:59+00:00","discovered_at":"2026-05-14T18:02:44.550640+00:00","generated_at":"2026-05-17T06:38:19.306307+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Monopar reports positive long-term neurological data for ALXN1840 in Wilson disease","bullets":["Pooled efficacy from 3 trials (n=255) showed sustained neurological improvement on UWDRS Part II & III over 6 years.","Patients crossing from standard of care to ALXN1840 showed additional neurological improvement, reversing prior worsening.","Psychiatric improvement sustained over multiple years per Brief Psychiatric Rating Scale (BPRS).","Safety: <1% drug-related neurological serious adverse events across >645 patient-years on ALXN1840.","Data presented at ANA Annual Meeting; builds on hepatic efficacy data from EASL 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001437749-25-029005","json":"https://secwatch.observer/filing/0001437749-25-029005.json","markdown":"https://secwatch.observer/filing/0001437749-25-029005.md","text":"https://secwatch.observer/filing/0001437749-25-029005.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1645469/000143774925029005/0001437749-25-029005-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1645469/000143774925029005/mnpr20250912_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T06:38:19.306307+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}