other material
confidence high
sentiment positive
materiality 0.65
Genprex reports positive preclinical GPX-002 data in T2D; first NHP achieved normal glucose tolerance at 7 months
Genprex, Inc.
- First T2D NHP received intraductal AAV infusion of GPX-002 (Pdx1+MafA) and showed normal glucose tolerance test at 7 months.
- Second NHP via direct pancreas injection improved glucose tolerance at 3 months but did not reach normal levels.
- T2D mice treated with GPX-002 showed reversal of hyperglycemia and normal glucose levels at 4 weeks post-surgery.
- GPX-002 aims to rejuvenate exhausted beta cells; company says data supports potential to address 90-95% of diabetes patients (T2D).
- Preclinical studies continuing; formal toxicology and IND submission planned.