---
schema_version: "secwatch.filing_event.v1"
accession: "0001437749-26-031199"
form_type: "8-K"
ticker: "MBRX"
cik: "0001659617"
company_name: "Moleculin Biotech, Inc."
filed_at: "2026-09-25T17:05:32+00:00"
generated_at: "2026-10-12T13:20:53.870382+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.4
calibrated_materiality_score: 0.4
confidence: "high"
source: SEC EDGAR
---

# Moleculin preclinical data: Annamycin pancreatic cancer activity partly mediated by CD8+ T cells

## Summary
- Preclinical data: Annamycin's pancreatic cancer activity is partially mediated by CD8+ T cells, suggesting an immune-mediated mechanism beyond direct cytotoxicity.
- Data presented at AACR Conference on Pancreatic Cancer, Sept 25–28, 2026, at Hilton San Diego Bayfront; abstract published in Sept 15, 2026 Cancer Research supplement.
- Presenter: Angela T. Alistar, MD (Morristown Medical Center, Atlantic Health System / Carol G. Simon Cancer Center); abstract title: 'Turning cold pancreatic tumors hot'.
- Annamycin is not currently in clinical development for pancreatic cancer; lead program remains MIRACLE trial in relapsed/refractory AML, the basis of near-term milestones.
- CEO Walter Klemp: data point to 'unexpected additional benefit'; if observation holds, it broadens where Annamycin might be useful and how it might be combined.

## SEC filing metadata
- accession: 0001437749-26-031199
- form_type: 8-K
- ticker: MBRX
- cik: 0001659617
- company_name: Moleculin Biotech, Inc.
- filed_at: 2026-09-25T17:05:32+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.4
- calibrated_materiality_score: 0.4
- confidence: high
- sec_items: 7.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1659617/000143774926031199/0001437749-26-031199-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1659617/000143774926031199/mbrx20260924_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001437749-26-031199
- JSON: https://secwatch.observer/filing/0001437749-26-031199.json
- Plain text: https://secwatch.observer/filing/0001437749-26-031199.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.