{"schema_version":"secwatch.filing_event.v1","accession":"0001438533-23-000030","form_type":"8-K","ticker":"TVTX","cik":"0001438533","company_name":"Travere Therapeutics, Inc.","filed_at":"2023-05-31T23:59:59+00:00","discovered_at":"2026-05-14T18:03:38.877269+00:00","generated_at":"2026-06-14T10:20:40.071507+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Travere reports positive Phase 1/2 COMPOSE Cohort 6 data for pegtibatinase in HCU","bullets":["Pegtibatinase 2.5 mg/kg twice weekly reduced total homocysteine (tHcy) by mean 67.1% vs placebo increase of 0.6%.","All 4 treated patients achieved mean tHcy below 100 µM threshold; one patient with low baseline achieved normalization.","No treatment-related serious adverse events, anaphylaxis, or discontinuations in cohort 6.","Methionine reduced and cystathionine elevated, consistent with desired CBS enzyme activity.","Company plans to initiate Phase 3 program by end of 2023 after regulatory engagement."],"urls":{"canonical":"https://secwatch.observer/filing/0001438533-23-000030","json":"https://secwatch.observer/filing/0001438533-23-000030.json","markdown":"https://secwatch.observer/filing/0001438533-23-000030.md","text":"https://secwatch.observer/filing/0001438533-23-000030.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1438533/000143853323000030/0001438533-23-000030-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1438533/000143853323000030/tvtx-20230531.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-14T10:20:40.071507+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}