{"schema_version":"secwatch.filing_event.v1","accession":"0001453687-25-000091","form_type":"8-K","ticker":"RNAC","cik":"0001453687","company_name":"Cartesian Therapeutics, Inc.","filed_at":"2025-05-30T23:59:59+00:00","discovered_at":"2026-05-14T18:02:48.333030+00:00","generated_at":"2026-05-20T04:14:29.270015+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.5,"calibrated_materiality_score":0.5,"confidence":"high","headline":"Cartesian Therapeutics enrolls first patient in Phase 3 AURORA trial of Descartes-08 for myasthenia gravis","bullets":["First participant enrolled in randomized, placebo-controlled Phase 3 AURORA trial of Descartes-08 (CAR-T) in ~100 patients with AChR Ab+ myasthenia gravis.","Descartes-08 is administered outpatient without preconditioning chemotherapy; primary endpoint is proportion with MG-ADL improvement ≥3 points at Month 4.","Phase 2b data cited: average 4.8-point MG-ADL reduction at Month 12; in biologic-naive subgroup 7.1-point reduction and 57% minimal symptom expression.","Safety profile consistent with prior data; continues to support outpatient administration without integrating vectors or conditioning chemotherapy."],"urls":{"canonical":"https://secwatch.observer/filing/0001453687-25-000091","json":"https://secwatch.observer/filing/0001453687-25-000091.json","markdown":"https://secwatch.observer/filing/0001453687-25-000091.md","text":"https://secwatch.observer/filing/0001453687-25-000091.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1453687/000145368725000091/0001453687-25-000091-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1453687/000145368725000091/rnac-20250530.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-20T04:14:29.270015+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}