{"schema_version":"secwatch.filing_event.v1","accession":"0001493152-24-006266","form_type":"8-K","ticker":"FBLG","cik":"0001958777","company_name":"FibroBiologics, Inc.","filed_at":"2024-02-14T23:59:59+00:00","discovered_at":"2026-05-14T18:03:26.375182+00:00","generated_at":"2026-06-06T02:43:25.138982+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.5,"calibrated_materiality_score":0.5,"confidence":"high","headline":"FibroBiologics preclinical data: HDF spheroids cut psoriasis severity 35% in mice","bullets":["Presented at 2024 Keystone Symposia on Systemic Autoimmune and Autoinflammatory Diseases.","Single IV dose of HDF spheroids reduced average PASI score by 35% (p<0.0001) in IMQ-induced psoriasis mouse model.","Spheroids also ameliorated IMQ-induced spleen enlargement and normalized lymphocyte and monocyte counts.","In vitro, HDFs inhibited TNF-α and IL-17 and suppressed dendritic cell maturation via CD40/CD80/CD86 downregulation.","Company holds 150+ issued/pending patents; data supports IND-enabling studies for early-discovery psoriasis program."],"urls":{"canonical":"https://secwatch.observer/filing/0001493152-24-006266","json":"https://secwatch.observer/filing/0001493152-24-006266.json","markdown":"https://secwatch.observer/filing/0001493152-24-006266.md","text":"https://secwatch.observer/filing/0001493152-24-006266.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1958777/000149315224006266/0001493152-24-006266-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1958777/000149315224006266/form8-k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-06T02:43:25.138982+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}