other material
confidence high
sentiment negative
materiality 0.85
Cassava discloses potential unblinding in Phase 2b study; collaborator indicted by DOJ
FILANA THERAPEUTICS, INC.
- DOJ indicted Dr. Wang for allegedly causing false statements to NIH about simufilam; company terminated his consulting.
- Internal investigation found senior employee may have unblinded Dr. Wang to some Phase 2b participants before bioanalysis.
- Reported Phase 2b CANTAB analysis excluded ~42% of subjects for episodic memory; results reflect smaller analysis set.
- Phase 3 trials fully enrolled (~1,900 patients), remain blinded; independent firms will handle bioanalysis.