---
schema_version: "secwatch.filing_event.v1"
accession: "0001493152-24-046434"
form_type: "8-K"
ticker: "CLDI"
cik: "0001855485"
company_name: "Calidi Biotherapeutics, Inc."
filed_at: "2024-11-18T23:59:59+00:00"
generated_at: "2026-05-29T23:13:50.322974+00:00"
event_type: "other_material"
sentiment: "neutral"
materiality_score: 0.4
calibrated_materiality_score: 0.4
confidence: "medium"
source: SEC EDGAR
---

# Calidi presents RTNova data supporting systemic targeting of metastatic lung cancer at IOVC and SITC

## Summary
- Data presented at IOVC and SITC shows RTNova enveloped virotherapy can target multiple metastatic tumor sites.
- RTNova uses tumor-selective vaccinia virus engineered to produce high levels of EEVs to avoid immune clearance.
- In an advanced lung metastasis model, RTNova demonstrated robust therapeutic potential as monotherapy and viral vector.
- The platform can induce expression of engineered payloads in tumor cells, enabling future delivery of therapeutic genes.
- Calidi plans to advance RTNova as a multi-modal systemic antitumor virotherapy and seek pharma collaborations.

## SEC filing metadata
- accession: 0001493152-24-046434
- form_type: 8-K
- ticker: CLDI
- cik: 0001855485
- company_name: Calidi Biotherapeutics, Inc.
- filed_at: 2024-11-18T23:59:59+00:00
- event_type: other_material
- sentiment: neutral
- materiality_score: 0.4
- calibrated_materiality_score: 0.4
- confidence: medium
- sec_items: 7.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1855485/000149315224046434/0001493152-24-046434-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1855485/000149315224046434/form8-k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001493152-24-046434
- JSON: https://secwatch.observer/filing/0001493152-24-046434.json
- Plain text: https://secwatch.observer/filing/0001493152-24-046434.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.