Serina Therapeutics presents data showing POZ-lipid avoids anti-PEG immune response in animal model

Serina Therapeutics, Inc.

POZ-lipid did not induce IgM or IgG antibody responses after repeated administration in an animal model.
Standard PEG-lipids used in mRNA vaccines (Pfizer-BioNTech, Moderna) elicited robust IgM and IgG responses.
Anti-PEG responses are linked to hypersensitivity reactions including anaphylaxis; POZ-lipid may enable safer LNP formulations.
Randall Moreadith, MD, PhD, Chief Development Officer, presented at the 3rd Annual LNP Immunogenicity & Toxicity Summit in Boston.

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