secwatch.observer — SEC 8-K summary ====================================== Issuer: Shuttle Pharmaceuticals Holdings, Inc. (SHPH) CIK: 0001757499 Form: 8-K Filed at: 2025-11-21T23:59:59+00:00 Accession: 0001493152-25-024618 Event type: other_material Sentiment: negative Materiality: 0.85 Item codes: 1.01, 1.02, 2.05, 9.01 LLM model: deepseek-v4-flash:cloud@v2 Shuttle Pharma discontinues Ropidoxuridine trial, settles $557K debt for $300K ------------------------------------------------------------------------------ - Settlement with Theradex: $300K payment in full for ~$557K debt; both parties release claims. - Company discontinues clinical trials of Ropidoxuridine; ends enrollment and begins FDA-compliant winddown. - Additional ~$750K owed to five hospital research sites under separate agreements. - Expects majority of winddown costs in Q4 2025; amount still being assessed. - Interim CEO Christopher Cooper signs filing; trial termination follows Theradex's Oct 15 termination notice. Source: EDGAR index: https://www.sec.gov/Archives/edgar/data/1757499/000149315225024618/0001493152-25-024618-index.htm Primary doc: https://www.sec.gov/Archives/edgar/data/1757499/000149315225024618/form8-k.htm HTML page: https://secwatch.observer/filing/0001493152-25-024618 License: Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer