---
schema_version: "secwatch.filing_event.v1"
accession: "0001493152-25-029361"
form_type: "8-K"
ticker: "SHPH"
cik: "0001757499"
company_name: "Shuttle Pharmaceuticals Holdings, Inc."
filed_at: "2025-12-29T23:59:59+00:00"
generated_at: "2026-05-16T12:07:14.154907+00:00"
event_type: "m_and_a"
sentiment: "negative"
materiality_score: 0.7
calibrated_materiality_score: 0.7
confidence: "high"
source: SEC EDGAR
---

# Shuttle Pharma issues 19.99% stake (320,496 shares) in accelerated asset purchase payment

## Summary
- First Amendment to Asset Purchase Agreement dated Dec 23, 2025 accelerates partial payment in stock.
- Issued 320,496 shares of common stock at $1.76/share, representing 19.99% of outstanding shares.
- Remaining First Installment Payment of $2,435,927.64 to be paid in cash only, per terms.
- Amendment modifies definition of First Installment Payment and Purchase Price to reflect accelerated issuance.
- Shares issued in unregistered transaction under Section 4(a)(2) and Rule 506(b)/Reg S.

## SEC filing metadata
- accession: 0001493152-25-029361
- form_type: 8-K
- ticker: SHPH
- cik: 0001757499
- company_name: Shuttle Pharmaceuticals Holdings, Inc.
- filed_at: 2025-12-29T23:59:59+00:00
- event_type: m_and_a
- sentiment: negative
- materiality_score: 0.7
- calibrated_materiality_score: 0.7
- confidence: high
- sec_items: 1.01, 3.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1757499/000149315225029361/0001493152-25-029361-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1757499/000149315225029361/form8-k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001493152-25-029361
- JSON: https://secwatch.observer/filing/0001493152-25-029361.json
- Plain text: https://secwatch.observer/filing/0001493152-25-029361.txt

## Source-grounded claims
- claim_id: f2ebf330b51afd67b32097d33e25bd5eef57ecf7
  claim: Shuttle Pharmaceuticals Holdings, Inc. amended First Amendment to Asset Purchase Agreement with 1563868 B.C. Ltd., 1542770 BC Ltd., ZhiTian (Andy) Zhang valued at 320,496 shares of Company Common Stock at $1.76 per share (effective 2025-12-23).
  evidence_excerpt: On December 23, 2025 (the “ Effective Date ”), Shuttle Pharmaceuticals Holdings, Inc. (the “ Company ”) entered into a First Amendment (the “ Amendment ”) to Asset Purchase Agreement (the “ Agreement ”) with 1563868 B.C. Ltd., a Canadian limited corporation and the Company’s wholly owned subsidiary (“ Purchaser ”), 1542770 BC Ltd., a Canadian limited corporation (“ Seller ”), and ZhiTian (Andy) Zhang, an individual residing in Vancouver, Canada (“ Seller Guarantor ”), dated as of November 20, 2025.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1757499/000149315225029361/0001493152-25-029361-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.