{"schema_version":"secwatch.filing_event.v1","accession":"0001493152-26-043053","form_type":"8-K","ticker":"TELO","cik":"0001971532","company_name":"Telomir Pharmaceuticals, Inc.","filed_at":"2026-09-17T12:30:40+00:00","discovered_at":"2026-09-17T12:35:01.516859+00:00","generated_at":"2026-09-17T12:35:10.207346+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Telomir reports peer-reviewed study: Telomir-Zn restores retinal structure/function in AMD model","bullets":["Telomir-Zn restored visual function and retinal structure after 14 days oral treatment in zebrafish AMD model; published in Int. J. Mol. Sci. 2026, 27(18), 8265.","Treatment reduced mitochondrial oxidative stress and restored thickness across multiple retinal layers including outer/inner nuclear, outer plexiform, and ganglion cell layers.","Telomir-Zn inhibited Fe²⁺-dependent Jumonji C histone demethylases across KDM2/KDM5/KDM6 families, strongest against KDM5B (IC50 63 nM).","Dose-dependent increase in relative telomeric DNA content toward wild-type profile and restoration of DNA methylation at aging-associated CpG loci.","Clinical priority remains oncology: FDA-cleared Phase 1/2 trial of Telomir-Zn in advanced or metastatic triple-negative breast cancer."],"urls":{"canonical":"https://secwatch.observer/filing/0001493152-26-043053","json":"https://secwatch.observer/filing/0001493152-26-043053.json","markdown":"https://secwatch.observer/filing/0001493152-26-043053.md","text":"https://secwatch.observer/filing/0001493152-26-043053.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1971532/000149315226043053/0001493152-26-043053-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1971532/000149315226043053/form8-k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-09-17T12:35:10.207346+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}