{"schema_version":"secwatch.filing_event.v1","accession":"0001503802-25-000006","form_type":"8-K","ticker":"KPTI","cik":"0001503802","company_name":"Karyopharm Therapeutics Inc.","filed_at":"2025-09-11T23:59:59+00:00","discovered_at":"2026-05-14T18:02:44.153110+00:00","generated_at":"2026-05-17T06:52:17.688538+00:00","sec_items":["5.02"],"event_type":"leadership","sentiment":"neutral","materiality_score":0.35,"calibrated_materiality_score":0.35,"confidence":"high","headline":"Karyopharm Therapeutics director Mansoor Raza Mirza resigns from board effective Sept 8, 2025","bullets":["Mansoor Raza Mirza, M.D. resigned from the Board of Directors due to competing professional demands.","Resignation effective September 8, 2025; not due to any disagreement with the Company.","Consulting agreement with Mirza Consulting terminated effective September 8, 2025.","Dr. Mirza also resigning as Chief Oncologist at Copenhagen University National Medical Center effective Oct 1, 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001503802-25-000006","json":"https://secwatch.observer/filing/0001503802-25-000006.json","markdown":"https://secwatch.observer/filing/0001503802-25-000006.md","text":"https://secwatch.observer/filing/0001503802-25-000006.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1503802/000150380225000006/0001503802-25-000006-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1503802/000150380225000006/kpti-20250905.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T06:52:17.688538+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}