---
schema_version: "secwatch.filing_event.v1"
accession: "0001503802-25-000006"
form_type: "8-K"
ticker: "KPTI"
cik: "0001503802"
company_name: "Karyopharm Therapeutics Inc."
filed_at: "2025-09-11T23:59:59+00:00"
generated_at: "2026-05-17T06:52:17.688538+00:00"
event_type: "leadership"
sentiment: "neutral"
materiality_score: 0.35
calibrated_materiality_score: 0.35
confidence: "high"
source: SEC EDGAR
---

# Karyopharm Therapeutics director Mansoor Raza Mirza resigns from board effective Sept 8, 2025

## Summary
- Mansoor Raza Mirza, M.D. resigned from the Board of Directors due to competing professional demands.
- Resignation effective September 8, 2025; not due to any disagreement with the Company.
- Consulting agreement with Mirza Consulting terminated effective September 8, 2025.
- Dr. Mirza also resigning as Chief Oncologist at Copenhagen University National Medical Center effective Oct 1, 2025.

## SEC filing metadata
- accession: 0001503802-25-000006
- form_type: 8-K
- ticker: KPTI
- cik: 0001503802
- company_name: Karyopharm Therapeutics Inc.
- filed_at: 2025-09-11T23:59:59+00:00
- event_type: leadership
- sentiment: neutral
- materiality_score: 0.35
- calibrated_materiality_score: 0.35
- confidence: high
- sec_items: 5.02
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1503802/000150380225000006/0001503802-25-000006-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1503802/000150380225000006/kpti-20250905.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001503802-25-000006
- JSON: https://secwatch.observer/filing/0001503802-25-000006.json
- Plain text: https://secwatch.observer/filing/0001503802-25-000006.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.