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confidence high
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materiality 0.80
BioVie announces positive Phase 2 results for NE3107 in Parkinson's and Alzheimer's; epigenetic age reduced 3.3 years
BIOVIE INC.
- PD trial: NE3107+levodopa improved UPDRS Part 3 by 3+ points vs levodopa alone; under-70 patients saw 6-point superiority.
- AD trial: 2.1-point improvement on ADAS-Cog12 (p=0.0173) in MCI/mild AD patients; CSF p-tau reduced by 1.66 pg/mL.
- 18 of 22 AD patients showed improvement on functional MRI; no drug-related adverse events reported.
- DNA methylation analysis: Horvath SkinBlood clock reduced by 3.3 years (p=0.0021) after 3 months; 19 of 22 patients showed reduction.
- Full Parkinson's data to be presented at AD/PD 2023 conference in March-April 2023.