{"schema_version":"secwatch.filing_event.v1","accession":"0001558370-23-002835","form_type":"8-K","ticker":"ACRS","cik":"0001557746","company_name":"Aclaris Therapeutics, Inc.","filed_at":"2023-03-06T23:59:59+00:00","discovered_at":"2026-05-14T18:03:45.561581+00:00","generated_at":"2026-06-18T11:32:45.623353+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Aclaris Phase 2a zunsemetinib trial for hidradenitis suppurativa fails to meet endpoints","bullets":["Study did not meet primary endpoint of change in inflammatory nodule/abscess count at week 12.","Secondary endpoints including HiSCR-50 also not met; placebo effect higher than in published HS studies.","Zunsemetinib generally well tolerated; most common AEs: dizziness (16.7%), diarrhea (12.5%), headache (12.5%).","No serious adverse events or opportunistic infections observed; PK/PD consistent with prior studies.","CEO notes next data readout from Phase 2b rheumatoid arthritis study is expected."],"urls":{"canonical":"https://secwatch.observer/filing/0001558370-23-002835","json":"https://secwatch.observer/filing/0001558370-23-002835.json","markdown":"https://secwatch.observer/filing/0001558370-23-002835.md","text":"https://secwatch.observer/filing/0001558370-23-002835.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1557746/000155837023002835/0001558370-23-002835-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1557746/000155837023002835/acrs-20230306x8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-18T11:32:45.623353+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}