---
schema_version: "secwatch.filing_event.v1"
accession: "0001558370-23-003644"
form_type: "8-K"
ticker: "MGTX"
cik: "0001735438"
company_name: "MeiraGTx Holdings plc"
filed_at: "2023-03-14T23:59:59+00:00"
generated_at: "2026-06-18T03:31:34.667926+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# MeiraGTx reports 2022 net loss $129.6M; pipeline advances toward 2024 BLA

## Summary
- Net loss of $129.6M ($2.87/share) vs $79.6M in 2021; revenue $15.9M (down from $37.7M on lower milestone payments).
- Cash and equivalents $115.5M plus $21M Janssen receivables; expected runway into Q4 2024.
- Phase 3 Lumeos trial for botaretigene sparoparvovec (XLRP) enrolling; BLA submission on track for 2024.
- AAV-hAQP1 for xerostomia showed 75% symptom improvement; Phase 2 planned Q2 2023.
- AAV-GAD for Parkinson's dosing patients; enrollment completion anticipated Q3 2023.

## SEC filing metadata
- accession: 0001558370-23-003644
- form_type: 8-K
- ticker: MGTX
- cik: 0001735438
- company_name: MeiraGTx Holdings plc
- filed_at: 2023-03-14T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1735438/000155837023003644/0001558370-23-003644-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1735438/000155837023003644/mgtx-20230314x8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001558370-23-003644
- JSON: https://secwatch.observer/filing/0001558370-23-003644.json
- Plain text: https://secwatch.observer/filing/0001558370-23-003644.txt

## Key facts
- Earnings Releases
  MeiraGTx Holdings plc reported financial results for the year ended December 31, 2022.
  - Period: the year ended December 31, 2022
  - Result: reported results
  source text: On March 14, 2023, MeiraGTx Holdings plc (the “Company”) issued a press release announcing its financial results for the year ended December 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1735438/000155837023003644/0001558370-23-003644-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.