other material
confidence high
sentiment positive
materiality 0.65
Bio-Path completes second dose cohort in Phase 1/1b trial of BP1002 in AML
BIO-PATH HOLDINGS, INC.
- Second dose cohort (40 mg/m²) completed in dose escalation for refractory/relapsed AML patients, including venetoclax-resistant.
- Trial will pause for FDA data review; next planned dose is 60 mg/m² in monotherapy.
- BP1002 targets Bcl-2 at mRNA level, may overcome venetoclax resistance; preclinical data showed potent inhibition.
- Phase 1b combination with decitabine expected after monotherapy cohorts; enrollment rates described as good.