{"schema_version":"secwatch.filing_event.v1","accession":"0001558370-25-001435","form_type":"8-K","ticker":"PMN","cik":"0001374339","company_name":"ProMIS Neurosciences Inc.","filed_at":"2025-02-25T23:59:59+00:00","discovered_at":"2026-05-14T18:03:03.463130+00:00","generated_at":"2026-05-26T04:38:59.256987+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.55,"calibrated_materiality_score":0.55,"confidence":"high","headline":"ProMIS Neurosciences doses first patients in Phase 1b PRECISE-AD trial of PMN310 for Alzheimer's disease","bullets":["First patients dosed in Phase 1b PRECISE-AD trial evaluating PMN310, a humanized mAb targeting toxic Aβ oligomers.","Interim six-month results expected in 1H 2026; topline results anticipated in 2H 2026.","PMN310 selectively targets soluble amyloid-beta oligomers, avoiding monomers and plaques, potentially differentiating from current AD therapies.","Rapid enrollment underscores unmet need for better AD treatments; investigators note need for effective and well-tolerated options."],"urls":{"canonical":"https://secwatch.observer/filing/0001558370-25-001435","json":"https://secwatch.observer/filing/0001558370-25-001435.json","markdown":"https://secwatch.observer/filing/0001558370-25-001435.md","text":"https://secwatch.observer/filing/0001558370-25-001435.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1374339/000155837025001435/0001558370-25-001435-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1374339/000155837025001435/pmn-20250225x8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-26T04:38:59.256987+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}