{"schema_version":"secwatch.filing_event.v1","accession":"0001558370-25-004796","form_type":"8-K","ticker":"MTVA","cik":"0001638287","company_name":"MetaVia Inc.","filed_at":"2025-04-15T23:59:59+00:00","discovered_at":"2026-05-14T18:02:49.159937+00:00","generated_at":"2026-05-23T14:41:55.055103+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"MetaVia reports positive Phase 1 MAD data for DA-1726 obesity drug: 6.3% max weight loss, strong glucose control","bullets":["Mean weight loss 4.3% (max 6.3%) at 32 mg dose on Day 26 (p=0.0005).","Fasted glucose lowered by mean 5.3 mg/dL (max 18 mg/dL); waist circumference reduced mean 1.6 in (max 3.9 in).","No SAEs or discontinuations; mild GI AEs transient, 83% of 32 mg cohort reported early satiety.","Adding higher-dose cohorts to determine MTD; planning Phase 1 Part 3 in Wegovy early drop-out patients.","Company cites balanced GLP-1/glucagon activation as potential best-in-class profile for safety and efficacy."],"urls":{"canonical":"https://secwatch.observer/filing/0001558370-25-004796","json":"https://secwatch.observer/filing/0001558370-25-004796.json","markdown":"https://secwatch.observer/filing/0001558370-25-004796.md","text":"https://secwatch.observer/filing/0001558370-25-004796.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1638287/000155837025004796/0001558370-25-004796-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1638287/000155837025004796/mtva-20250415x8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-23T14:41:55.055103+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}