{"schema_version":"secwatch.filing_event.v1","accession":"0001558370-25-009139","form_type":"8-K","ticker":"MTVA","cik":"0001638287","company_name":"MetaVia Inc.","filed_at":"2025-07-09T23:59:59+00:00","discovered_at":"2026-05-14T18:02:44.539117+00:00","generated_at":"2026-05-18T08:53:38.593995+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"MetaVia doses first patient in 48 mg MAD cohort of Phase 1 obesity trial; Q4 top-line data expected","bullets":["First patient dosed in 48 mg multiple ascending dose cohort of DA-1726 (GLP1R/GCGR dual agonist) for obesity.","Prior 32 mg data: mean weight loss 4.3%, max 6.3% at Day 26 (p=0.0005); 83% early satiety; average waist reduction 1.6 inches by Day 33.","Fasting glucose reduced up to 18 mg/dL without hypoglycemia; no QTcF prolongation; mild GI side effects, suggesting favorable tolerability.","CEO stated DA-1726 has best-in-class potential with no titration needed; top-line results from 48 mg cohort expected Q4 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001558370-25-009139","json":"https://secwatch.observer/filing/0001558370-25-009139.json","markdown":"https://secwatch.observer/filing/0001558370-25-009139.md","text":"https://secwatch.observer/filing/0001558370-25-009139.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1638287/000155837025009139/0001558370-25-009139-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1638287/000155837025009139/mtva-20250709x8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-18T08:53:38.593995+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}