Aclaris ATI-2138 Phase 2a AD trial meets primary and key secondary endpoints; 60.5% mean EASI improvement at week 12

Aclaris Therapeutics, Inc.

14 patients enrolled; 10 per protocol; no SAEs or discontinuations; well tolerated with mild, transient TRAEs.
Mean EASI improvement 60.5% (77.1% excluding one outlier); 62.5% achieved ≥4-point itch reduction at week 12.
PD data show near-complete ITK target occupancy and downregulation of Th2, Th1/Th17, and fibrosis markers.
Company plans to further develop ATI-2138 in alopecia areata and explore other indications.
Preclinical work ongoing for next-gen ITK inhibitors; new INDs expected starting 2026.

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