---
schema_version: "secwatch.filing_event.v1"
accession: "0001564590-21-057143"
form_type: "8-K"
ticker: "SYRE"
cik: "0001636282"
company_name: "Spyre Therapeutics, Inc."
filed_at: "2021-11-16T23:59:59+00:00"
generated_at: "2026-06-28T07:48:31.885181+00:00"
event_type: "leadership"
sentiment: "neutral"
materiality_score: 0.3
calibrated_materiality_score: 0.3
confidence: "high"
source: SEC EDGAR
---

# Aeglea Biotherapeutics appoints Hunter Smith to board of directors and audit committee

## Summary
- Hunter Smith appointed as Class I director and Audit Committee member effective November 12, 2021.
- Smith is CFO of Rhythm Pharmaceuticals (since July 2017) and previously VP Finance at Celgene.
- Receives pro rata director retainer ($40,000 annual) and audit committee retainer ($7,500 annual).
- Granted option to purchase 60,000 shares at closing price on November 12, 2021, vesting monthly over three years.

## SEC filing metadata
- accession: 0001564590-21-057143
- form_type: 8-K
- ticker: SYRE
- cik: 0001636282
- company_name: Spyre Therapeutics, Inc.
- filed_at: 2021-11-16T23:59:59+00:00
- event_type: leadership
- sentiment: neutral
- materiality_score: 0.3
- calibrated_materiality_score: 0.3
- confidence: high
- sec_items: 5.02
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1636282/000156459021057143/0001564590-21-057143-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1636282/000156459021057143/agle-8k_20211112.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001564590-21-057143
- JSON: https://secwatch.observer/filing/0001564590-21-057143.json
- Plain text: https://secwatch.observer/filing/0001564590-21-057143.txt

## Key facts
- Executive change
  Hunter Smith was appointed as Class I Director at Spyre Therapeutics, Inc..
  - Action: appointed
  - Role: Class I Director
  source text: On November 12, 2021, the board of directors (the “Board”) of Aeglea Biotherapeutics, Inc. (the “Company”) appointed Hunter Smith as a Class I director and as a member of the Audit Committee, effective immediately.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1636282/000156459021057143/0001564590-21-057143-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.