{"schema_version":"secwatch.filing_event.v1","accession":"0001564590-23-000832","form_type":"8-K","ticker":"SANA","cik":"0001770121","company_name":"Sana Biotechnology, Inc.","filed_at":"2023-01-26T23:59:59+00:00","discovered_at":"2026-05-14T18:03:46.476183+00:00","generated_at":"2026-06-20T08:23:28.674877+00:00","sec_items":["8.01","9.01"],"event_type":"regulatory","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Sana Biotechnology receives FDA IND clearance for SC291 allogeneic CAR T therapy in B-cell malignancies","bullets":["FDA cleared IND for SC291, a CD19-targeted allogeneic CAR T therapy using Sana's hypoimmune platform, in patients with B-cell lymphomas or leukemias.","Goal to report initial SC291 clinical data in 2023; second IND for SC262 (CD22-targeted) expected this year.","Hypoimmune platform disrupts MHC class I/II expression and overexpresses CD47 to evade immune rejection.","Preclinical data shown across models; platform also being developed for pancreatic islet cell therapy in type 1 diabetes."],"urls":{"canonical":"https://secwatch.observer/filing/0001564590-23-000832","json":"https://secwatch.observer/filing/0001564590-23-000832.json","markdown":"https://secwatch.observer/filing/0001564590-23-000832.md","text":"https://secwatch.observer/filing/0001564590-23-000832.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1770121/000156459023000832/0001564590-23-000832-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1770121/000156459023000832/sana-8k_20230126.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-20T08:23:28.674877+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}