{"schema_version":"secwatch.filing_event.v1","accession":"0001599298-25-000137","form_type":"8-K","ticker":"SMMT","cik":"0001599298","company_name":"Summit Therapeutics Inc.","filed_at":"2025-09-08T23:59:59+00:00","discovered_at":"2026-05-14T18:02:44.460130+00:00","generated_at":"2026-05-17T07:36:22.150645+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Ivonescimab HARMONi trial shows improved OS trend in longer follow-up; North American HR=0.70","bullets":["Longer-term follow-up of Western patients: OS HR=0.78 (nominal p=0.0332); median OS 16.8 vs 14.0 months.","North American patients: median OS not reached for ivonescimab vs 14.0 months for placebo (HR=0.70).","Primary PFS analysis showed HR=0.52 (p<0.00001); median PFS 6.8 vs 4.4 months.","Overall response rate higher with ivonescimab (45% vs 34%); median duration of response 7.6 vs 4.2 months.","Safety profile manageable; TRAEs leading to discontinuation 7.3% (ivonescimab) vs 5.0% (placebo)."],"urls":{"canonical":"https://secwatch.observer/filing/0001599298-25-000137","json":"https://secwatch.observer/filing/0001599298-25-000137.json","markdown":"https://secwatch.observer/filing/0001599298-25-000137.md","text":"https://secwatch.observer/filing/0001599298-25-000137.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1599298/000159929825000137/0001599298-25-000137-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1599298/000159929825000137/smmt-20250907.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T07:36:22.150645+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}