{"schema_version":"secwatch.filing_event.v1","accession":"0001601485-26-000046","form_type":"8-K","ticker":"ELTX","cik":"0001601485","company_name":"Elicio Therapeutics, Inc.","filed_at":"2026-06-15T13:21:02+00:00","discovered_at":"2026-06-15T13:22:00.325539+00:00","generated_at":"2026-06-15T13:22:10.717921+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Elicio Phase 2 AMPLIFY-7P misses primary DFS endpoint; positive R0 subgroup guides Phase 3","bullets":["AMPLIFY-7P did not meet primary endpoint of DFS in ITT; R1 resection imbalance (19% vs 10%) favored observation arm.","Post-hoc analysis in R0 patients showed HR 0.65 (p=0.048); mDFS 23.8 mo vs 12.8 mo; 84% of study population.","mKRAS-specific T cell responses strongly correlated with DFS (HR 0.22, p<0.0001, n=90).","Refined Phase 3 plan targets R0 resected patients with additional dosing; cash runway into Q4 2026; exploring financing.","Favorable safety: no treatment-related discontinuations or deaths."],"urls":{"canonical":"https://secwatch.observer/filing/0001601485-26-000046","json":"https://secwatch.observer/filing/0001601485-26-000046.json","markdown":"https://secwatch.observer/filing/0001601485-26-000046.md","text":"https://secwatch.observer/filing/0001601485-26-000046.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1601485/000160148526000046/0001601485-26-000046-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1601485/000160148526000046/angn-20260615.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-15T13:22:10.717921+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}