other material
confidence high
sentiment positive
materiality 0.75
Recursion completes Phase 1 study for REC-3964; drug well tolerated, Phase 2 planned for 2024
RECURSION PHARMACEUTICALS, INC.
- Phase 1 study of REC-3964 in healthy volunteers completed; no serious adverse events reported.
- 42 participants in MAD part; doses up to 900 mg for 14 days; PK dose-proportional, half-life 7-10 hrs.
- Treatment-related AEs in 11.8% (4/34) of REC-3964 recipients, all mild; no discontinuations.
- Phase 2 proof-of-concept trial in recurrent C. diff infection expected to start in 2024.
- REC-3964 is novel non-antibiotic small molecule inhibitor of C. diff toxins; >730k cases US/EU5 annually.