secwatch / observer

8-K filed December 8, 2025, 6:59 PM ET ticker RXRX CIK 0001601830

other material confidence high sentiment positive materiality 0.80

Recursion reports positive Phase 1b/2 data for REC-4881 in FAP: 75% show polyp burden reduction

RECURSION PHARMACEUTICALS, INC.

75% of evaluable patients reduced total polyp burden at 12 weeks; median reduction 43%.
At 25 weeks (12 weeks off therapy), 82% maintained reduction with 53% median decrease from baseline.
40% of patients achieved ≥1-point improvement in Spigelman stage (upper GI disease severity).
Safety profile consistent with MEK1/2 inhibition; no Grade ≥4 TRAEs reported to date.
Company to engage FDA in 1H26 for registration pathway; trial expanding to ages ≥18.

item 8.01 item 9.01

Machine-readable event card

schema_version: secwatch.filing_event.v1
accession: 0001601830-25-000174
form_type: 8-K
ticker: RXRX
cik: 0001601830
company_name: RECURSION PHARMACEUTICALS, INC.
filed_at: 2025-12-08T23:59:59+00:00
discovered_at: 2026-05-14T18:02:39.885316+00:00
generated_at: 2026-05-16T13:58:25.789572+00:00
sec_items: ["8.01", "9.01"]
event_type: other_material
sentiment: positive
materiality_score: 0.8
calibrated_materiality_score: 0.8
confidence: high
secwatch_canonical_url: https://secwatch.observer/filing/0001601830-25-000174
json_url: https://secwatch.observer/filing/0001601830-25-000174.json
markdown_url: https://secwatch.observer/filing/0001601830-25-000174.md
text_url: https://secwatch.observer/filing/0001601830-25-000174.txt
edgar_index_url: https://www.sec.gov/Archives/edgar/data/1601830/000160183025000174/0001601830-25-000174-index.htm
edgar_primary_document_url: https://www.sec.gov/Archives/edgar/data/1601830/000160183025000174/rxrx-20251208.htm
generated_by_model: deepseek-v4-flash:cloud@v2
review_status: machine_generated
human_reviewed: false
corrected: false
correction_note: null
correction_timestamp: null
superseded_by: null

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