{"schema_version":"secwatch.filing_event.v1","accession":"0001619856-22-000036","form_type":"8-K","ticker":"CRBU","cik":"0001619856","company_name":"Caribou Biosciences, Inc.","filed_at":"2022-12-12T23:59:59+00:00","discovered_at":"2026-05-14T18:03:51.461421+00:00","generated_at":"2026-06-21T06:10:28.059838+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Caribou: 12-month CB-010 data shows durable CR in 2/6; selects ROR1 for CB-020","bullets":["CB-010 ANTLER cohort 1: 6/6 CR best response; 3/6 durable CR at 6 months; 2/6 maintain CR at 12 months; longest CR 18 months.","FDA granted CB-010 RMAT and Fast Track designations; dose level 2 (80x10^6) no DLTs; enrolling dose level 3 (120x10^6).","Selected ROR1 as target for CB-020 iPSC-derived allogeneic CAR-NK cell therapy; preclinical data shows significant tumor burden reduction in xenograft model.","Armoring strategies for CAR-NK platform: CBLB knockout, B2M knockout with HLA-E insertion, membrane-bound IL-15/IL-15RA fusion."],"urls":{"canonical":"https://secwatch.observer/filing/0001619856-22-000036","json":"https://secwatch.observer/filing/0001619856-22-000036.json","markdown":"https://secwatch.observer/filing/0001619856-22-000036.md","text":"https://secwatch.observer/filing/0001619856-22-000036.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1619856/000161985622000036/0001619856-22-000036-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1619856/000161985622000036/crbu-20221212.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-21T06:10:28.059838+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}