---
schema_version: "secwatch.filing_event.v1"
accession: "0001628280-23-004846"
form_type: "8-K"
ticker: "XNCR"
cik: "0001326732"
company_name: "Xencor Inc"
filed_at: "2023-02-23T23:59:59+00:00"
generated_at: "2026-06-19T02:05:45.682338+00:00"
event_type: "earnings"
sentiment: "negative"
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: "high"
source: SEC EDGAR
---

# Xencor Q4 2022 net loss $12M vs net income $73.1M; revenue $21.6M down 86% YoY

## Summary
- Net loss per share $(0.20) vs EPS $1.21 in Q4 2021; full year net loss $55.2M.
- Total revenue $21.6M in Q4 2022 vs $154.0M in Q4 2021; full year revenue $164.6M vs $275.1M.
- Cash and securities $613.5M as of Dec 31, 2022; expects to end 2023 with $425-475M.
- R&D expenses $51.5M in Q4, comparable to prior year; full year R&D $199.6M up from $192.5M.
- Initiated Phase 1 for XmAb819 (ENPP3xCD3) and XmAb808 (B7-H3xCD28); IND for XmAb541 planned.

## SEC filing metadata
- accession: 0001628280-23-004846
- form_type: 8-K
- ticker: XNCR
- cik: 0001326732
- company_name: Xencor Inc
- filed_at: 2023-02-23T23:59:59+00:00
- event_type: earnings
- sentiment: negative
- materiality_score: 0.75
- calibrated_materiality_score: 0.75
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1326732/000162828023004846/0001628280-23-004846-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1326732/000162828023004846/xncr-20230223.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001628280-23-004846
- JSON: https://secwatch.observer/filing/0001628280-23-004846.json
- Plain text: https://secwatch.observer/filing/0001628280-23-004846.txt

## Key facts
- Earnings Releases
  Xencor Inc reported the fiscal year ended December 31, 2022 results: revenue $164.6 million.
  - Period: the fiscal year ended December 31, 2022
  - Revenue: $164.6 million
  - Result: reported results
  source text: Revenues for the full year 2022 were $164.6 million compared to $275.1 million for the same period in 2021.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1326732/000162828023004846/0001628280-23-004846-index.htm
- Earnings Releases
  Xencor Inc reported the fourth quarter ended December 31, 2022 results: revenue $21.6 million.
  - Period: the fourth quarter ended December 31, 2022
  - Revenue: $21.6 million
  - Result: reported results
  source text: Total revenue for the fourth quarter ended December 31, 2022 was $21.6 million compared to $154.0 million for the same period in 2021.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1326732/000162828023004846/0001628280-23-004846-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.